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gVCFs for Targeted Resequenced data

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Hi

For targeted re-sequenced data, can we do variant calling using HaplotypeCaller in gVCF mode followed by using GenotypeGVCFs for joint genotyping ?

Would the following best practices work for targeted re-sequencing as well , except for VQSR as for targted resequencing GATK advices another way of filtering. https://www.broadinstitute.org/gatk/guide/best-practices?bpm=DNAseq

Thanks, Tinu


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